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tokin' at the crag

Tony B · · Around Boulder, CO · Joined Jan 2001 · Points: 24,690
Who Dat wrote: Adderall IS amphetamine. Atoms matter. Precisely, it's a combination of mixed salts with varying half lives which produces the long-acting effect.

Yeah, as for atoms mattering, that's what I said. And if you understood that you would not have called it what you did. It's not a witches brew, it's a specific structure. Here, let me help you.
Amphetamine:



Methamphetamine:


And the end effect is not just about half-life, pharmicokentics is not the only difference. It's also about affinity, boding affinity, stability and/or meta-stability, etc... Even the size of the molecule matters since penetration into the cytosol is part of the mechanism of action.

Jesus Christ, you'd think a nurse of all people would get that.

Because Atoms matter, and amphetamine is not methamphetamine (methylalphamethylphenethylamine) in the same way that amphetamine is not methylenedioxymethamphetamine, which is also not methamphetamine.
Just because 'amphetamine' is in the name, doesn't mean they even act on the same transporters! (IE: SERT Vs. DAT)
Who Dat · · Spinning Rock, MW · Joined Dec 2014 · Points: 5
Tony B wrote: Yeah, as for atoms mattering, that's what I said. And if you understood that you would not have called it what you did. It's not a witches brew, it's a specific structure. Here, let me help you. Amphetamine: Methamphetamine: And the end effect is not just about half-life, pharmicokentics is not the only difference. It's also about affinity, boding affinity, stability and/or meta-stability, etc... Even the size of the molecule matters since penetration into the cytosol is part of the mechanism of action. Jesus Christ, you'd think a nurse of all people would get that. Because Atoms matter, and amphetamine is not methamphetamine (methylalphamethylphenethylamine) in the same way that amphetamine is not methylenedioxymethamphetamine, which is also not methamphetamine. Just because 'amphetamine' is in the name, doesn't mean they even act on the same transporters! (IE: SERT Vs. DAT)

I'm not really sure why this is in response to my post. That's what I said - the methyl group matters.

You are correct. MDMA is not methamphetamine either.. what's your point?

I was referring to Adderall XR which is what most folks think of when they think Adderall. Are you going to tell me that it isn't a racemic mixture of AMPHETAMINE salts? Take the 10mg capsule for example: Amphetamine Aspartate 2.5mg, Amphetamine Sulfate 2.5mg, Dextroamphetamine Saccharate 2.5mg, Dextroamphetamine Sulfate 2.5mg.

If we're going to start talking about PK and pKa's we may be on the wrong forum.

Boissal . · · Small Lake, UT · Joined Aug 2006 · Points: 1,541
Tony B wrote: Drivel

You're out of your element Donny...

Tony B · · Around Boulder, CO · Joined Jan 2001 · Points: 24,690
Who Dat wrote: I'm not really sure why this is in response to my post.

Because I took this:

Who Dat wrote: Precisely, it's a combination of mixed salts with varying half lives which produces the long-acting effect.

To mean a broad mixture, not specifically of Amphetamine salts, which you specified this time.
Rereading it, yes, it made sense and I misread you. I never thought I'd offer a genuine appalogy to Elanor, but there you have it. Sorry about that.

Boissal wrote: You're out of your element Donny...

Yes, somewhat. I studied neurobiology and neuropharmacology, not chemistry.
So feel free to explain what part is drivel, as you put it, in detail.
I'm up for learning if you have something to offer.

Who Dat · · Spinning Rock, MW · Joined Dec 2014 · Points: 5
Tony B wrote: Because I took this: To mean a broad mixture, not specifically of Amphetamine salts, which you specified this time. Rereading it, yes, it makes sense.

Yes, amphetamine salts is what I meant. I suppose I should have been more specific.

Colonel Mustard · · Sacramento, CA · Joined Sep 2005 · Points: 1,257
Tony B wrote: Jesus Christ, you'd think a nurse of all people would get that.

I wouldn't. Beyond major side effects and drug interactions, nurses are too busy dealing with a whole lot of shit to start playing molecular scientist/pharmacist.

Derek Jf · · Northeast · Joined Feb 2012 · Points: 335

where are we on the opinion... everyone safe yet?

Healyje · · PDX · Joined Jan 2006 · Points: 422

Probably want to steer clear of the Pacific Northwest crags if you are at all concerned about non-contact highs.

Doug Meneke · · Unknown Hometown · Joined Apr 2013 · Points: 5

I don't care if anyone is poking smot. I don't like the dam cigarette smoke.

Tim Stich · · Colorado Springs, Colorado · Joined Jan 2001 · Points: 1,516
Chick on Crack wrote:SO, perhaps Cliff Bar should come out with "edible" Mojo.

As if. They lost their climber cred. And, I doubt they can compete with Nacho Cheese Doritos for the stoner vote.

M Mobley · · Bar Harbor, ME · Joined Mar 2006 · Points: 911
Healyje wrote:Probably want to steer clear of the Pacific Northwest crags if you are at all concerned about non-contact highs.

What does a non contact high feel like? Is it a myth? I only ask cause I've never had one.

climb already · · Unknown Hometown · Joined Dec 2014 · Points: 10

Why is this thread still rambling on?

Climbers have smoked pot while climbing for decades and still do. It's legal in CO to smoke pot.
If you choose to smoke while climbing, that is entirely your call. Please be careful and don't hurt yourself but it is your business entirely.

If you think smoking pot and climbing is a bad idea (and you have a right to that opinion), you don't have to do it. If others are doing it, it isn't any of your business unless they are somehow putting you in potential danger (e.g. your belayer is high).

Bottom line- have fun climbing. Don't worry about what other people are doing & let others take responsibility for their own decisions.

'nuff said?

iceman777 · · Colorado Springs · Joined Oct 2007 · Points: 60
Nick Grant wrote:A hard-drinking slab climber with two bum knees from Southern Colorado told me that when Jimmy Dunn climbed Cosmos (it was an FA and the first new route ever soloed on El Cap), he was tripping for much of the climb. Supposedly, one of the guys who did the second ascent of Cosmos said that it was "like following the path of a madman."

I doubt it , but I'll ask jimmy . Jimmy recanted a totally different story to me about the FA of cosmos .

Now if your talking super crack it's my understanding it was done on shrooms .

I really don't care if you smoke I just wish that it didn't all smell like burning sagebrush that's been dragged through dogshit after being pissed on by a mongloid deer . I grew up in Humbolt county and I've never smelled anything a horrible as you folks are smoking . WTF.

I'm convinced not one of you would know good weed if someone fisted it up your ass or your all too cheap to buy the good stuff .proably the latter .

Franck Vee · · Unknown Hometown · Joined Apr 2017 · Points: 260

I think I'd be scared shitless to get on the sharp end while high. I think indoor bouldering is about as far (or as... high hahaha) that I might go.

It's not necessarily about the underlying safety of it all. I think it is somewhat less safe, even if you ovecompensate by triple-checking everything. Maybe I'm just careless while high, but even if I'm super carefull in the kitchen not to make a mess with those pancakes, I still end up with an unexplicable strawberry jelly stain on my left shoulder. So climbing, not sue.... It's more that knowing myself, I'd just freak out.

Chalk Norris · · Vallecito, CO · Joined Nov 2006 · Points: 279

This is silly,

I remember that day...we showed up to the slips in boulder ready to climb some easy 5.9's for my friend.  I am a boulder native and have climbed these routes numerous times.  After climbing edges and ledges, we decided to take a "safety break".  During this time, 2 other gentlemen showed up, one old and one younger.  We disregarded the party and continued our safety meeting before roping up for the next easy climb.  I have been partaking in MJ for years and it does not affect my or my partner when climbing other than getting munchies and some cotton mouth.  It was funny, that this other party could barely climb the routes we were doing high as a kite and we witnessed them take a cheese grading fall on easy terrain while sober.  Everyone was polite and minded their own business because everything was safe.  Those that partake regularly can handle themselves with poise and elegance(some more than others) while climbing.  No one got hurt(remember we got safe before climbing).  Anyways, I meant to post 2 years ago but thought the thread disappeared.  If you dont like MJ being used dont move to colorado.  Everyone has their vices and you wont see me judging you when you show up all hyped up on your double espresso ready for the sharp end or hungover which I think is way more unsafe.  I climb high everytime, I try to be polite and move away from other parties while indulging.  Smoke pot, check your knot.  Smoke crack, sell your rack.  Dont get scared and have fun out there.  If you see me in bocan I am more than happy to lead the route for you that might be too hard and always willing to share the trees.  Have fun out there! 

Chalk Norris

Rich Brereton · · Pownal, ME · Joined May 2009 · Points: 175
iceman777 wrote: I doubt it , but I'll ask jimmy . Jimmy recanted a totally different story to me about the FA of cosmos . Now if your talking super crack it's my understanding it was done on shrooms . I really don't care if you smoke I just wish that it didn't all smell like burning sagebrush that's been dragged through dogshit after being pissed on by a mongloid deer . I grew up in Humbolt county and I've never smelled anything a horrible as you folks are smoking . WTF. I'm convinced not one of you would know good weed if someone fisted it up your ass or your all too cheap to buy the good stuff .proably the latter .

Franck thanks for randomly responding to a dead thread from years ago... otherwise I never would have seen this, which has to be some of the funniest shit ever posted to MP

MisterE Wolfe · · Nevada City, CA · Joined Dec 2007 · Points: 8,037
ECTradClimber wrote: Smoke pot, check your knot.

Doubled back, bowl to pack!

Kurt G · · Monticello, UT · Joined Nov 2012 · Points: 156

not sure if it got mentioned, i only skimmed the comments, but watch Valley Uprising for a good look at the link between the two

Aleks Zebastian · · Boulder, CO · Joined Jul 2014 · Points: 175

climbing friend,

JonasMR · · Unknown Hometown · Joined Feb 2016 · Points: 6

The one I never figured out was smoking after the climb, but before the rap.  Why not wait till the ground?  Or enjoy climbing high?

Guideline #1: Don't be a jerk.

Colorado
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