If placed in a horizontal crack, an offset cam is not bigger on top or bottom. It would be bigger to the left or right. The offset would be better than a normal cam only if the crack is tapering left or right. What you’re referring to is the common advice of placing the wider lobes of a normal cam on the bottom in a horizontal placement for more stability. This does not apply to offset cams because the direction of the crack taper dictates the offset cam orientation. You can’t just flip an offset cam like a normal cam- the big/small lobes would then switch.
For a diagonal crack, it depends on the angle and the flare/taper. The angle of the diagonal changes the direction of pull. But in general, the taper or flare of a crack will dictate the need for an offset cam, not the angle of the crack.