The Interior is inclusive of most of the main land-locked regions of the state, not bordered by coasts. The largest city in the Interior is Fairbanks, which is about 8 hours by car, north of Anchorage. This huge expanse of land includes the Alaska Range, which is where the highest peak in North America is located, Mt.Mckinley/Denali.
Depending on what part of the interior you are travelling to, it might be ideal to land in Fairbanks, or Anchorage International Airport and then bush plane or car.