De Beque Canyon is a narrow canyon cut by the Colorado River. The rock in the canyon is Mesa Verde Sandstone, of highly variable quality. There are climbable buttresses throughout the canyon, often with difficult approaches and questionable rock quality. There are several established climbs in the canyon, and although the rock quality is hit or miss, the scenery and solitude of the canyon is capital. There are a tremendous amount of possibilities for route development in the area.

De Beque Canyon is approximately 15 miles (24 km) long, located on the Colorado River downstream from the town of De Beque, in eastern Mesa County. The canyon forms a narrow passage where the river passes along the western end of the Grand Mesa. At its lower end, the canyon opens out on the eastern end of the Grand Valley at the town of Palisade, approximately 10 miles (16 km) east of Grand Junction.