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Tissue Issue is a tall, thin face climb that is in a tight corridor near J-Crack. The landing is hideous with a pointed immovable rock at the base. Any fall will land you square on this obstacle. It is shaped perfectly to snap an ankle. I would seriously suggest headpointing this problem with a rope prior to bouldering it, and I almost never even consider this option. It negates the point of bouldering, but considering the difficulty and danger of this problem, may be prudent.
The problem climbs a steep, thin face on diagonal edges with prickly rock and tiny foot chips. The first couple of moves are very crimpy. Exit up and to the right. Prior to the first ascent by Dr. Torretti, it was a long eyed project. The difficulty and danger kept mortals off of it, until Joel committed to it. I doubt that it has seen more than a couple of ascents to this day, ten years later.
Tissue Issue is the tall, prickly looking face that is in a corridor near the entrance to the Cave proper that is on the side of the Stables entrance. It is across from an easy, featured face which has the E Face problems on it.
Many pads and spotters, or a top rope. There is an ankle breaking rock at the base. If you had 4 or more pads, the landing might (not a promise) be okay.