In my opinion, the direct start adds plenty of quality to Frustration Syndrome as it converts the route into a much more sustained multi-cruxed route. A good friend of mine describes climbing at the Gunks as little, big adventures. This route is certainly a little big adventure with a committing start, a few moderate moves at the upper overhang and great moves in between.
Begin a couple feet to the left of the obvious left-facing corner which starts ~25' off the deck. Climb straight up the steep face (unprotected crux) to a good stance just to the left of the left-facing corner. You can either get good pro here to your left (watch rope drag) or can traverse right to the corner for great pro (if you look for it) which is in line with the route. Climb the corner as per Frustration Syndrome, finishing by pulling the overhang above the corner and reaching a two-bolt anchor.
Location
Walk about 20 minutes along the Carriage Road to the Slime Wall/Wasp approach trail. Frustration Syndrome can be found toward the right side of the Slime Wall.
Protection
As with many harder Gunks routes, don't forget the micronuts. Don't bother with anything larger than a .5 C4. Great nut placements abound.